Overview and anatomy

  1. Intermittent fasting reduces inflammation and oxidative stress, increasing the number and quality of mitrochondria
  2. Vocabulary
    • Mastication - chewing
    • Deglutition - swallowing
    • Eructation - burping
    • Emesis - vomiting
    • Borborygmi - stomach grumbling
    • Postprandial - post meal
  3. Digestive system is functionally "outside" of the body, and 15 feet long
  4. Four processes of the digestive system - Digestion, absorption, motility, secretion - the last two are continuously regulated by gut stimuli via the ENS and CNS
  5. Long reflexes are initiated by sight, smell, and taste of food
  6. Distension of peptides and amino acids initiate short reflexes
  7. Three phrases of digestion
    • Cephalic phase - oral and esophageal - initiated by stimuli and characterized by an activated PNS, preparing stomach for food and digestion
    • Gastric phase - storage, mixing, digestion and protection
    • Intestinal phase - digestion and absorption through the use of bicarbonate, mucus, bile, enzymes (enteropeptidase)
  8. Large intestine concentrates waste for excretion
  9. The vagus nerve innervates the upper GI system - esophagus, stomach, pancreas, intestine, upper colon
  10. The pelvic nerve innervates the lower descending colon, rectum, and anus
  11. PNS is excitatory for GI function, SNS is inhibitory
  12. Spinal cord injury can disrupt GI function - e.g. involuntary defecation
  13. Congenital aganglionic megacolon (Hirschsprung disease) is where there's improper differentiation between the myenteric (Auerbach's) plexus and the submucosal (Meissner's) plexus in the distal part of the colon (sigmoid) and rectum - due in part to a lack of an enteric ganglion along with variable length of colon and inadequate motility
  14. Accessory organs of GI system include liver and pancreas - and salivary glands
  15. Sphincters include the UES, LES, Pyloric valve (in stomach), internal and external anal sphincters, ileocecal valve, and sphincter of Oddi - which moves bile from pancreas to intestines
  16. GI tract has four layers
    • Mucosa - epithelial, lamina propia, muscularis mucosae
    • Submucosa
    • Muscularis externa - made of oblique, circular, and longitudinal muscle
    • Serosa
  17. Proximal 1/3 of stomach is for storage, distal 2/3 for secretion and motility
  18. Intestinal villi increase surface area, crypts help absorb, enterocytes help absorb
  19. Celiac disease is caused by damage to microvilli and villi due to T-cell response