Endocrine Pharmacology I - Hypothalamus and Pituitary
- GnRH stimulates FSH and LH
- GHRH stimulates GH
- Somatostatin inhibits GH and TSH
- TRH (thyrotropin) stimulates TSH and Prolactin
- VIP stimulates Prolactin
- Dopamine inhibits Prolactin and TSH
- CRH, ADH stimulate ACTH and endorphins
- ADH and oxytocin are stored in the posterior pituitary, others in the anterior
- Tesamorelin (test) is a synthetic form of GHRH used to diagnose GHRH and HR sufficiency or treat adiposity in HIV patients
- Somatropin is recombinant growth hormone used in treating deficiency
- Mecasermin is a recombinant form of IGF-1, for use in children who don't respond to GH
- Gigantism occurs if excessive GH prior to fusion of long bones, acromegaly if excessive GH afterwards
- Pegvisomant is a growth hormone antagonist - can elevate liver enzymes and induce lipodystrophy
- Octreotide and lanreotide are SST analogs
- Bromocriptine and cabergoline are dopamine agonists that can reduce growth hormone release in high doses
- Domperidone can stimulate prolactin production as a dopamine receptor antagonist
- Bromocriptine and cabergoline are dopamine agonists used to suppress prolactin release
- Atosiban is an oxytocin antagonist
- Vasopressin and desmopressin can treat diabetes insipidus
- The -vaptans are vasopressin receptor antagonists, and Tolvaptan can only be given for 30 days due to hepatotoxicity concerns